By car
Highways A-62 and A-66 will lead you to the city.
To get there from Madrid, you need to follow highway A-50.
If you arrive in Salamanca by car, you will find different options for parking and convenient access to the city center. You can choose between public parking, underground parking, regulated parking zones, other parking areas located outside the ORA zone and commuter parking

There are regular bus lines that, with their corresponding connections, allow you to reach Salamanca from any Spanish or European city. Companies like Flix Bus or Alsa offer bus connections to Portugal (Porto, Coimbra, and Lisbon).
There is a direct bus line operated by Monbus from Madrid-Barajas airport to Salamanca. The stop at Barajas is located in Terminal 1 of the airport, in the parking lot in front of the arrivals hall; there is also one in T4. Tickets for this service and timetables can be checked on their website www.monbus.es, at usual ticket offices, and within the airport itself, at the El Corte Inglés travel agency, located on the first floor of T1. You can also call: +34 91 272 28 32. From Madrid-Barajas airport, to reach Madrid's South Bus Station (C/ Méndez Álvaro), the best option is to take metro line nº 8 to Nuevos Ministerios station and then line nº 6 to Méndez Álvaro. You can also take a taxi if you don't want to change lines. Madrid's tourist information phone number is +34 91 578 78 10.

Salamanca Bus Station: Avenida Filiberto Villalobos 71, 37007 Salamanca + 34 923 23 67 17

If you prefer to travel by train, RENFE offers daily connections to Madrid and all its onward services. To get from Madrid Barajas Airport to Madrid's Chamartín Train Station, you need to take Metro Line 8 to Nuevos Ministerios station, and then change to Line 10, which will take you to Chamartín. Alvia train services operate on the electrified Salamanca – Medina del Campo line, allowing the journey between Madrid and Salamanca to be completed in 1 hour and 36 minutes, reducing the current travel time (2 h 39 min) by 63 minutes. The medium-distance train departs from Príncipe Pío station. You can check all schedules on their website: www.renfe.es or call them at +34 919 19 05 04.
The Metro website is https://www.metromadrid.es/
Salamanca Train Station. Avda de la Estación s/n /37004 Salamanca